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agate
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Joined: 17 May 2006
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 Posted: Mon May 29, 2006 11:30 pm Post subject: (Abstract) Stroke after interferon-beta treatment for RRMS |
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Acta Neurol Scand. 2006 Jun;113(6):433-6.
Stroke after initiation of interferon-beta treatment for relapsing-remitting disseminated white matter disease.
Bosche B, Dohmen C, Impekoven P, Weber OZ, Reske D, Rubbert A, Jacobs AH, Petereit HF.
Department of Neurology, University of Cologne, Germany.
Background - Interferon-beta (INF-beta) is effective and used in reducing exacerbation frequency and disease progression in multiple sclerosis. In certain circumstances, INF-beta can lead to rare side effects.
Aims of the study - We report the case of a 34-year-old female patient satisfying the McDonald criteria of multiple sclerosis without showing typical pathologic changes in cerebrospinal fluid (CSF). After introduction of INF-beta treatment, she quickly developed further progression of her disseminated neurological symptoms and finally an ischemic cerebral infarction.
Methods - Evaluation of the patient included arterial angiography, magnetic resonance and positron emission tomography, histopathological assessment as well as a broad spectrum of serum and CSF analysis.
Results - All diagnostic evaluations and the clinical course revealed evidences for a primary angiitis of the CNS. We discuss the possible worsening due to inappropriate INF-beta treatment in cerebral angiitis promoting severe cerebrovascular insufficiency.
Conclusion - The authors suggest that all diagnostic multiple sclerosis criteria including typical CSF findings should be ascertained before INF-beta treatment is initiated.
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