|
View previous topic :: View next topic |
Author |
Message |
agate Site Admin
Joined: 17 May 2006 Posts: 5694 Location: Oregon
|
Posted: Wed Sep 27, 2006 1:25 pm Post subject: (Abstract) Worse outcome for late-onset MS? |
|
|
From PubMed, 9/27/06:
Quote: |
Neurology. 2006 Sep 26;67(6):954-9.
Is late-onset multiple sclerosis associated with a worse outcome?
Tremlett H, Devonshire V.
Department of Medicine (Neurology), Rm. S159, 2211 Wesbrook Mall, University of British Columbia, Vancouver, BC V6T 2B5, Canada. tremlett@interchange.ubc.ca.
OBJECTIVE: To describe the characteristics of late-onset multiple sclerosis (MS) (LOMS, 50+ years) vs adult-onset MS (AOMS, 16 to <50 years) and examine prognosis and associated risk factors.
METHODS: Patients with definite MS, onset prior to July 1988, registered with a BCMS clinic before July 1998, with at least one Expanded Disability Status Scale (EDSS) score, were selected from the longitudinal population-based British Columbian (BC) MS database.
Clinical and demographic characteristics were compared between LO and AOMS. Progression was measured as time to reach sustained EDSS 6 and potential risk factors examined were sex, disease course (primary progressive [PP] vs relapsing [R]), and onset symptoms.
RESULTS: Of those eligible (n = 2,837), LOMS comprised 132 (4.7%), with PPMS predominating (54.5% vs 10.6% in AOMS, p < 0.0005). Motor onset symptoms were more prevalent in LOMS and sensory and optic neuropathy more prevalent in AOMS (p < 0.0005). AOMS averaged 27.7 years (95% CI: 26.3 to 29.1) to EDSS 6 from onset vs 16.9 years (95% CI: 9.0 to 24.8) in LOMS, p < 0.0005. However, AOMS was associated with a younger age at EDSS 6 (58.4 years [95% CI: 57.1 to 59.6] vs 71.2 years [95% CI: 65.2 to 77.3] in LOMS, p < 0.0005). There were no differences in progression between AO or LO for those with PPMS (p = 0.373) or R-MS (p = 0.438), although considerable variation was observed.
CONCLUSIONS: Late-onset multiple sclerosis (LOMS) is not necessarily associated with a worse outcome: first, progression in the primary progressive or relapsing patients differed little between late-onset vs adult-onset; secondly, those with LOMS were older when reaching Expanded Disability Status Scale 6. The disease course has a far greater implication for disease prognosis than the presence of LOMS.
|
|
|
Back to top |
|
|
|
|
You can post new topics in this forum You can reply to topics in this forum You can edit your posts in this forum You can delete your posts in this forum You cannot vote in polls in this forum
|
|
|