Bookmark this site!
Warning about resveratrol supplements for MS

 
Post new topic   Reply to topic    msspeaks Forum Index -> MS - RESEARCH, ARTICLES, ABSTRACTS, DISCUSSION
View previous topic :: View next topic  
Author Message
agate
Site Admin


Joined: 17 May 2006
Posts: 5694
Location: Oregon

PostPosted: Tue Oct 08, 2013 11:00 pm    Post subject: Warning about resveratrol supplements for MS Reply with quote

From Medical News Today, October 1, 2013:

Quote:


Warning about resveratrol supplements for MS

People with multiple sclerosis (MS) are being warned against taking resveratrol supplements, after a new study using two MS models has found that the compound worsened MS-like neuropathology and inflammation, and had no neuroprotective effects.

Results of the study were published in The American Journal of Pathology.

Reservatrol is a naturally occurring polyphenol compound found in the skin of red grapes, red wine and peanuts, and it is believed to have anti-inflammatory and antioxidant properties.

This has been supported by some experimental studies, whereas others suggest a lack of benefit.

Lead investigator Dr. Ikuo Tsunoda, assistant professor in the Department of Microbiology and Immunology at the Center for Molecular & Tumor Virology of the Louisiana State University Health Sciences Center, says:

"Resveratrol may have detrimental effects in some disease conditions and should be discouraged for supplemental use by MS patients pending further research."

Effects of resveratrol in mice
The researchers tested resveratrol in autoimmune and viral models of MS in mice.

In the autoimmune model, they simulated an experimental autoimmune encephalomeylitis (EAE) using myelin oligodendrocyte glycoprotein peptide. The mice were then fed either a control diet or a diet containing resveratrol.

After 12 days, the mice all showed clinical signs, such as tail and hind limb paralysis, and the symptoms worsened and peaked by 3 weeks.

After 5 weeks, the mice eating the control diet recovered completely or suffered only mild paralysis, whereas mice on the resveratrol diet all exhibited severe and lasting EAE without remission.

Neuropathological tests on the spinal cords of the mice also showed higher pathology scores for demyelination, meningitis and inflammation for those fed the resveratrol diet. There was no evidence that resveratrol suppressed autoimmune responses, leading the researchers to conclude that it did not have any anti-inflammatory properties.

Further experiments conducted to test whether resvertrol had any anti-viral properties again cast doubt about the claims.

Mice were infected with the Daniels (DA) strain of Theiler's murine encephalomyelitis virus (TMEV) to induce TMEV-induced demyelinating disease (TMEV-IDD).

The findings here showed that the mice fed on the resveratrol diet developed significantly more severe TMEV-IDD than the control group.

The degree to which resveratrol exacerbated demyelination and inflammation surprised the research team.

"Our findings illustrate that caution should be exercised for potential therapeutic application of resveratrol in human inflammatory demyelination diseases, including MS," says Dr. Tsunoda.

The jury is still out on any benefits resveratrol may have. Recent studies have shown it is effective in treating vascular dementia, but a 2012 study queried any benefits for healthy women.

Written by Belinda Weber


The article can be seen here.
Back to top
View user's profile Send private message
Display posts from previous:   
Post new topic   Reply to topic    msspeaks Forum Index -> MS - RESEARCH, ARTICLES, ABSTRACTS, DISCUSSION All times are GMT - 7 Hours
Page 1 of 1

 
Jump to:  
You can post new topics in this forum
You can reply to topics in this forum
You can edit your posts in this forum
You can delete your posts in this forum
You cannot vote in polls in this forum
Create your own free forum now!
Terms of Service Purchase Ad Removal Forum Archive Report Abuse