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(Abst.) MS incidence & prevalence in UK 1990-2010...

 
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PostPosted: Sat Sep 21, 2013 12:44 pm    Post subject: (Abst.) MS incidence & prevalence in UK 1990-2010... Reply with quote

From PubMed, September 21, 2013:

Quote:
J Neurol Neurosurg Psychiatry. 2013 Sep 19.

Incidence and prevalence of multiple sclerosis in the UK 1990-2010: a descriptive study in the General Practice Research Database

Mackenzie IS, Morant SV, Bloomfield GA, Macdonald TM, O'Riordan J.

Medicines Monitoring Unit (MEMO), University of Dundee, Dundee, UK.

OBJECTIVES:

To estimate the incidence and prevalence of multiple sclerosis (MS) by age and describe secular trends and geographic variations within the UK over the 20-year period between 1990 and 2010 and hence to provide updated information on the impact of MS throughout the UK.

DESIGN:
A descriptive study.

SETTING:
The study was carried out in the General Practice Research Database (GPRD), a primary care database representative of the UK population.

MAIN OUTCOME MEASURES:

Incidence and prevalence of MS per 100,000 population. Secular and geographical trends in incidence and prevalence of MS.

RESULTS:

The prevalence of MS recorded in GPRD increased by about 2.4% per year (95% CI 2.3% to 2.6%) reaching 285.8 per 100,000 in women (95% CI 278.7 to 293.1) and 113.1 per 100,000 in men (95% CI 108.6 to 117.7) by 2010. There was a consistent downward trend in incidence of MS reaching 11.52 per 100 000/year (95% CI 10.96 to 12.11) in women and 4.84 per 100,000/year (95% CI 4.54 to 5.16) in men by 2010. Peak incidence occurred between ages 40 and 50 years and maximum prevalence between ages 55 and 60 years. Women accounted for 72% of prevalent and 71% of incident cases. Scotland had the highest incidence and prevalence rates in the UK.

CONCLUSIONS:

We estimate that 126,669 people were living with MS in the UK in 2010 (203.4 per 100,000 population) and that 6003 new cases were diagnosed that year (9.64 per 100,000/year). There is an increasing population living longer with MS, which has important implications for resource allocation for MS in the UK.

KEYWORDS:
Epidemiology, Multiple Sclerosis
PMID: 24052635


The abstract can be seen here.
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