(Abst.) Defining & scoring response to IFN-beta in MS

 
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PostPosted: Wed Jul 31, 2013 9:18 am    Post subject: (Abst.) Defining & scoring response to IFN-beta in MS Reply with quote

This article seems to be saying that the reason not much is known about how well any of the interferon-type MS drugs is working is that they don't yet know what to look for....

From PubMed, July 31, 2013:

Quote:
Nat Rev Neurol. 2013 Jul 30.

Defining and scoring response to IFN-β in multiple sclerosis.

Sormani MP, De Stefano N.

Department of Health Sciences (DISSAL), University of Genoa, Via Pastore 1, Genoa 16132, Italy.

The advent of a large number of new therapies for multiple sclerosis (MS) warrants the development of tools that enable selection of the best treatment option for each new patient with MS. Evidence from clinical trials clearly supports the efficacy of IFN-β for the treatment of MS, but few factors that predict a response to this drug in individual patients have emerged.

This deficit might be due, at least in part, to the lack of a standardized definition of the clinical outcomes that signify improvement or worsening of the disease. MRI markers and clinical relapses have been the most widely studied short-term factors to predict long-term response to IFN-β, although the results are conflicting.

Recently, integrated strategies combining MRI and clinical markers in scoring systems have provided a potentially useful approach for the management of patients with MS.

In this Review, we focus on the many definitions of clinical response to IFN-β and explore the markers that can be used to predict this response. We also highlight advantages and limitations of the existing scoring systems in light of future expansion of these models to biological markers and to other classes of emerging therapies for MS.

PMID: 23897407


The abstract can be seen here.
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