(Abst.) Uhthoff's phenomena in MS...

 
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PostPosted: Wed Jun 05, 2013 6:21 pm    Post subject: (Abst.) Uhthoff's phenomena in MS... Reply with quote

From PubMed, June 5, 2013:

Quote:
Nat Rev Neurol. 2013 Jun 4.

Uhthoff's phenomena in MS-clinical features and pathophysiology

Frohman TC, Davis SL, Beh S, Greenberg BM, Remington G, Frohman EM.

Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Centre, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA.

In the late 19th century, Wilhelm Uhthoff reported on a series of patients with acute optic neuritis who manifested similar recurrent, stereotyped visual symptoms that were of paroxysmal onset, short in duration, and reversible. These 'Uhthoff's phenomena', which are a feature of multiple sclerosis (MS) and other demyelinating diseases, can be triggered by factors including the perimenstrual period, exercise, infection, fever, exposure to high ambient temperatures, and psychological stress.

Here we characterize the clinical, pathophysiological and neurotherapeutic challenges associated with Uhthoff's phenomena and discuss the differentiation of these events from other paroxysmal, acute or subacute changes in functional capabilities and neurological symptoms in MS.

For instance, whereas MS exacerbations are contingent on immune dysregulation, Uhthoff's phenomena are predicated on ion channel modifications, in conjunction with thermoregulatory derangements that transiently alter the conduction properties of demyelinated axons.

An understanding of these pathophysiological underpinnings of Uhthoff's phenomena is germane to their recognition and timely treatment.

PMID: 23732530


The abstract can be seen here.
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