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agate Site Admin
Joined: 17 May 2006 Posts: 5694 Location: Oregon
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Posted: Tue Apr 09, 2013 12:06 pm Post subject: (AAN) Falls in people w/MS (US, Sweden) |
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Presented at the AAN conference in San Diego, March 16-23, 2013:
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[P04.106] Falls in People with MS: A Transatlantic Perspective
Michelle Cameron, Portland, OR, Ylva Nilsagard, Orebro, Sweden
OBJECTIVE:
To describe and compare fall rates and circumstances in people with MS (PwMS) in the United States (US) and Sweden.
BACKGROUND:
Falls are common in PwMS. No studies have compared fall rates and circumstances between countries.
DESIGN/METHODS:
52 PwMS in the US and 76 PwMS in Sweden recorded their falls, including fall location and timing, daily for 3 months using calendars. Negative binomial regression with a log link function was used to evaluate the impacts of country, age, EDSS, MS disease subtype, and sex on fall rate.
RESULTS:
Compared with the US cohort, the Swedish cohort was older (mean age 50.4 vs 39.7 years), more disabled (mean EDSS 4.70 vs 2.78), had more subjects with progressive disease (progressive 47% vs 6%; relapsing-remitting 53% vs 94%) and had more women (75% vs 69%).
Overall, 343 falls were recorded by 81/128 subjects. The cohorts had similar proportions of subjects who fell at least once in 3 months (Sweden 63.55, US 63%), fall locations (Indoors: Sweden 62.2%, US 63.5%), and fall timing (Afternoon: Sweden 43%, US 47.%%; night: Sweden 3%, US 6.6%).
However, the Swedish cohort had a higher fall rate (1.18 vs 0.47 falls/month) and a higher proportion of subjects with multiple falls (43% vs 25%).
EDSS was the only demographic feature that significantly predicted fall rate. After adjusting for all other effects, each step increase in EDSS was associated with a 49% increase in mean fall rate.
CONCLUSIONS:
Falls are common in PwMS in the US and Sweden. In these samples, the proportion of subjects who fell at least once in 3 months and the circumstances of falls were similar. However, the average fall frequency and proportion of [subjects?] with more than one fall were higher in the Swedish sample. EDSS, but not country, age, MS disease subtype or sex, was a predictor of fall frequency.
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Supported by:
Michelle Cameron was supported by a CDA-2 from the Department of Veterans Affairs Rehabilitation Research & Development Service. Ylva Nilsagård was supported by grants from the Örebro Research Committee. Michelle Cameron and Ylva Nilsagård were supported by a Jacqueline Du Pré award from the MS International Federation.
Category - MS and Related Diseases: Clinical Science
Wednesday, March 20, 2013 7:30 AM
Session P04: Multiple Sclerosis: Gait Analysis and Treatment |
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