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agate
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Joined: 17 May 2006
Posts: 5694
Location: Oregon
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 Posted: Wed Mar 27, 2013 1:22 pm Post subject: (AAN) Age-related recovery from acute ON in MS |
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Presented at the AAN conference in San Diego, March 16-23, 2013:
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[P04.120] Age Related Recovery from Acute Optic Neuritis in Multiple Sclerosis
Muhammad Taimur A. Malik, Brookline, MA, Brian Healy, Brookline, MA, Leslie Benson, Boston, MA, Tanuja Chitnis, Brookline, MA
OBJECTIVE:
To determine the severity and recovery from Acute Optic Neuritis (AON) episodes in both Pediatric-Onset Multiple Sclerosis (POMS) and Adult-Onset Multiple Sclerosis (AOMS) patients.
BACKGROUND:
AON attacks are common in both POMS and AOMS patients, but the severity and level of recovery from these attacks are variable across patients. Identification of predictors associated with attack severity and recovery may aid in clinical care.
DESIGN/METHODS:
Both the AOMS (n=68) and POMS patients (n=24) were identified from CLIMB study at Partners Adult and Pediatric MS Centers, who presented with AON as their initial symptom after the year 2000. For each attack, a chart review was completed to assess initial severity of attack and level of recovery from attack.
Severity was classified based on visual acuity at the visit closest to the attack. Attacks were classified as mild (20/40), moderate (20/50-20/190) and severe (>20/200).
Recovery from AON was classified based on the change in visual acuity at clinic visit, 1 year after onset. Recovery was classified as complete (20/20 or pre-attack acuity), fair (20/40) and poor (>20/50 or worse).
The proportion of patients with each level of severity and recovery for initial AON attack was compared in two groups using Fisher's exact test.
The probability of complete recovery including all attacks was assessed using generalized estimating equations.
RESULTS:
The proportion of AOMS patients with mild/moderate/severe AON attack at first symptom (13.4% /32.4%/54.4%) was not significantly different than in POMS (8.3%/25%/66.7%, p=0.66). Conversely, [the] proportion of POMS patients who experienced complete recovery from the initial AON attack was significantly higher than in AOMS (91% vs.70%, p=0.05).
When all AON attacks were considered (including first episode), POMS patients were more likely to experience complete recovery (p=0.03).
CONCLUSIONS:
Compared to AOMS, POMS patients are more likely to experience complete recovery from AON attacks.
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Supported by: NMSS RG-4256A4/2 and the Pediatric MS Centers of Excellence Award – NMSS.
Category - MS and Related Diseases: Clinical Science
Wednesday, March 20, 2013 7:30 AM
Session P04: Multiple Sclerosis: Disability Progression |
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