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(Abst.) Clinical outcome of 462 CCSVI-treated MS cases

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PostPosted: Mon Feb 04, 2013 11:59 pm    Post subject: (Abst.) Adverse events after CCSVI treatment in MS patients Reply with quote

From Multiple Sclerosis Journal, February 4, 2013:

(by the same group of authors as the previous post in this thread)

Adverse events after endovascular treatment of chronic cerebro-spinal venous insufficiency (CCSVI) in patients with multiple sclerosis

A Ghezzi1
P Annovazzi1
MP Amato2
E Capello3
P Cavalla4
E Cocco5
M Falcini6
A Gallo7
F Patti8
P Perini9
ME Rodegher10
M Rovaris11
MR Rottoli12
G Comi1,10
the MS Study Group-Italian Society of Neurology

1Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Italy
2Department of Neurosciences — University of Florence, Italy
3Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova
4Clinica Neurologica, Università di Torino, Italy
5Centro Sclerosi Multipla, Dipartimento di Sanità Pubblica, Medicina Clinica e Molecolare, University of Cagliari, Italy
6Multiple Sclerosis Center, Ospedale Misericordia e Dolce, Italy
7Multiple Sclerosis Centre, I Division of Neurology, Second University of Naples, Italy
8DANA GF Ingrassia, Neuroscience Section, Multiple Sclerosis Center, University of Catania, Italy
9Neurological Department, Azienda Ospedaliera Università di Padova, Italy
10Department of Neurology, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Italy
11Multiple Sclerosis Center, Fondazione Don Gnocchi, Italy
12Multiple Sclerosis Center, Dipartimento di Chirurgia del Sistema Nervoso e Neuroscienze, Ospedali Riuniti Bergamo, Italy

Although it is debated whether chronic cerebro-spinal venous insufficiency (CCSVI) plays a role in multiple sclerosis (MS) development, many patients undergo endovascular treatment (ET) of CCSVI. A study is ongoing in Italy to evaluate the clinical outcome of ET.

Severe adverse events (AEs) occurred in 15/462 subjects at a variable interval after ET: jugular thrombosis in seven patients, tetraventricular hydrocephalus, stroke, paroxysmal atrial fibrillation, status epilepticus, aspiration pneumonia, hypertension with tachicardia, or bleeding of bedsore in the remaining seven cases. One patient died because of myocardial infarction 10 weeks after ET.

The risk of severe AEs related to ET for CCSVI must be carefully considered.

The abstract can be seen here.
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