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(ECTRIMS) Alcohol as modifiable factor & MS risk

 
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PostPosted: Sat Oct 05, 2013 7:06 pm    Post subject: (ECTRIMS) Alcohol as modifiable factor & MS risk Reply with quote

Presented at the annual ECTRIMS conference in Copenhagen, October 2-5, 2013:

Quote:
Epidemiology

Thursday, October 03, 2013, 15:45 - 17:00

Alcohol as a modifiable lifestyle factor affecting multiple sclerosis risk

A.K. Hedström, J. Hillert, T. Olsson, L. Alfredsson (Stockholm, SE)

Background

The aim of this study was to investigate the possible influence of alcohol consumption on the risk of developing MS, and to relate the influence of alcohol to the effects of smoking.

Methods

This report is based on two Swedish population-based case-control studies, one with incident cases (n=745) and one with prevalent cases (n=5874). In both studies, subjects with different alcohol habits were compared with regard to occurrence of MS, by calculating odds ratios (OR) with 95% confidence intervals (95% CI) employing logistic regression. The potential interaction between drinking and smoking habits was evaluated by calculating the attributable proportion due to interaction (AP).

Results

There was a dose-dependent inverse association between alcohol consumption and the risk of developing MS that was statistically significant in both sexes. In EIMS [Epidemiological Investigation of Multiple Sclerosis], women who reported high alcohol consumption had an OR of 0.6 (95% CI 0.4-0.9) of developing MS compared with non-drinking women, whereas men with high alcohol consumption had an OR of 0.5 (0.2-1.0) compared with non-drinking men. The OR for the corresponding comparison in GEMS [Genes and Environment in Multiple Sclerosis] was 0.7 (0.6-0.9) for women, and 0.7 (0.2-1.0) for men.

Different types of alcoholic beverages had the same influence on MS risk. In both studies, the detrimental effect of smoking was more pronounced among non-drinkers.

Conclusions

Alcohol consumption exhibits a dose-dependent inverse association with MS. Furthermore, alcohol consumption is associated with attenuation of the effect of smoking. Alcohol consumption may thus be another modifiable life style factor that affects the risk of developing MS.

_________________

Dr. Hedström receives research support from the Swedish Association for Persons with Neurological Disabilities.

Dr. Hillert received honoraria for serving on advisory boards for BiogenIdec, Merck-Serono and Novartis and for speaker’s fees from BiogenIdec, Merck-Serono, Bayer-Schering, Teva and Sanofi-Aventis. He has served as P.I. for and received projects supported by BiogenIdec, Merck-Serono, and Bayer-Schering. His MS research is funded by the Swedish Research Council, Bibbi and Nils Jensens Foundation and the European Commission.

Dr. Olsson served on scientific advisory boards for Merck-Serono, Biogen Idec, and SanofiAventis; served as Co-editor of Current Opinion in Immunology; received speaker honoraria from Novartis and Biogen; and receives research support from Bayer Schering, Sanofi-Aventis, Biogen Idec, the Swedish Research Council, EU fp6 Neuropromise, EURATools, the Söderberg Foundation, Bibbi and Nils Jensens Foundation, the Montel Williams Foundation, and the Swedish Brain Foundation.

Dr. Alfredsson receives research support from the Swedish Medical Research Council and Swedish Council for Working life and Social Research. The work was supported by grants from the Swedish Medical Research Council; from the Swedish Council for Working Life and Social Research, the fp6 EU program Neuropromise, Bibbi and Niels Jensens foundation, Knut and Alice Wallenbergs Foundation, the Söderberg foundation, and the Swedish Association for Persons with Neurological Disabilities.
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