(Abst.) CCSVI: masked multimodal imaging assessment

 
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agate
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PostPosted: Fri Jul 05, 2013 8:46 pm    Post subject: (Abst.) CCSVI: masked multimodal imaging assessment Reply with quote

From Multiple Sclerosis Journal, July 4, 2013:

Quote:

Chronic cerebrospinal venous insufficiency: masked multimodal imaging assessment

Staley A Brod1
Larry A Kramer2
Alan M Cohen2
Andrew D Barreto1
Thanh-Tung Bui1
James R Jemelka1
Kelly Ton1
John W Lindsey1
Flavia Nelson1
Ponnada A Narayana2
Jerry S Wolinsky1

1Department of Neurology, University of Texas Health Science Center at Houston, USA
2Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, TX, USA
Jerry S. Wolinsky, University of Texas Health Science Center at Houston, MSMB 7.044, 6431 Fannin St., Houston, TX 77030, USA. Email: jerry.s.wolinsky@uth.tmc.edu


Background:

Chronic cerebrospinal venous insufficiency (CCSVI) was implicated in the pathophysiology of multiple sclerosis (MS).

Objective:

We evaluated neurosonography (NS), magnetic resonance venography (MRV), and transluminal venography (TLV) in subsets of MS patients drawn from a single-center, prospective, case-control study of 206 MS and 70 non-MS volunteers.

Methods:

As previously reported, findings on high-resolution B-mode NS imaging with color and spectral Doppler of the extracranial and intracranial venous drainage consistent with CCSVI were similar among MS and non-MS volunteers (3.88% vs 7.14%; p = 0.266).

Ninety-nine MS participants consented to intravascular contrast-enhanced 3D MRV to assess their major systemic and intracranial venous circulation, and 40 advanced to TLV that included pressure measurements of the superior vena cava, internal jugular, brachiocephalic, and azygous veins.

Results:

NS findings and MRV patterns were discrepant for 26/98 evaluable subjects, including four with abnormal findings on NS that had normal venous anatomy by MRV. In no instance were TLV pressure gradients indicative of clinically significant functional stenosis encountered. The three imaging approaches provided generally consistent data with discrepancies referable to inherent technique properties.

Conclusions:

Our findings lend no support for altered venous outflow dynamics as common among MS patients, nor do they likely contribute to the disease process.
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agate
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Joined: 17 May 2006
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Location: Oregon

PostPosted: Tue Jul 16, 2013 10:36 pm    Post subject: Reply with quote

The entire article can be seen here.
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