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agate Site Admin
Joined: 17 May 2006 Posts: 5694 Location: Oregon
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Posted: Wed Apr 17, 2013 10:15 am Post subject: "Clinically definite benign MS" unwarranted? |
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From Multiple Sclerosis Journal, April 17, 2013:
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‘Clinically definite benign multiple sclerosis’, an unwarranted conceptual hodgepodge: evidence from a 30-year observational study
E Leray1,2,3
M Coustans3
E Le Page2,3
J Yaouanq3,4
J Oger3,5
G Edan2,3
1Epidemiology Department, EHESP School of Public Health, Rennes, France
2CIC-P 0203 INSERM, Centre Hospitalier Universitaire, France
3Service de neurologie, Centre Hospitalier Universitaire, Rennes, France
4Service d’épidémiologie, Centre Hospitalier Universitaire, Rennes, France
5Vancouver Multiple Sclerosis Clinic, University of British Columbia, Canada
Gilles Edan, Service de neurologie, CHU Pontchaillou, 2 Rue Henri Le Guilloux, 35033 Rennes Cedex 9, France. Email: gilles.edan@chu-rennes.fr
Background:
Benign multiple sclerosis (BMS) is a controversial concept which is still debated. However identification of this kind of patients is crucial to prevent them from unnecessary exposure to aggressive and/or long term medical treatments.
Objectives:
To assess two definitions of ‘clinically definite benign multiple sclerosis’ (CDBMS) using long-term follow-up data, and to look for prognostic factors of CDBMS.
Methods:
In 874 patients with definite relapsing–remitting MS, followed up for at least 10 years, disability was assessed using the Disability Status Scale (DSS). CDBMS was defined by either DSS score≤2 (CDBMS1 group) or DSS score≤ 3 (CDBMS2 group) at 10 years. We estimated the proportion of patients who were still benign at 20 and 30 years after clinical onset.
Results:
CDBMS frequency estimates were 57.7% and 73.9% when using CDBMS1 and CDBMS2 definitions, respectively. In the CDBMS1 group, only 41.7% (105/252) of cases were still benign 10 years later, and 41.1% (23/56) after an additional decade, while there were 53.8% (162/301) and 59.5% (44/74) respectively in the CDBMS2 group.
Conclusions:
This 30-year observational study, which is one of the largest published series, indicates that favourable 10-year disability scores of DSS 2 or 3 fail to ensure a long-term benign course of multiple sclerosis. After every decade almost half of the CDBMS were no longer benign. CDBMS, as currently defined, is an unwarranted conceptual hodgepodge. Other criteria using new biomarkers (genetic, biologic or MRI) should be found to detect benign cases of MS.
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